Cfd Gene Summary [Rat]
Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfd |
| Official Name | complement factor D [Source:RGD Symbol;Acc:2498] |
| Ensembl ID | ENSRNOG00000033564 |
| Bio databases IDs | |
| Aliases | complement factor D |
| Synonyms | ADIPSIN, ADN, complement factor D, DF, EVE, Factor D, PFD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- endopeptidase
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- complement factor D
- peptidase
Pathways
Biological processes and signaling networks where the Cfd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- non-insulin-dependent diabetes mellitus
- thrombosis
- insulin resistance
- squamous-cell carcinoma
- non-small cell lung cancer
- gastric adenocarcinoma
- organismal death
- Alzheimer disease
- kidney disease
role in cell
- expression in
- phosphorylation in
- apoptosis
- differentiation
- proliferation
- migration
- tubulation
- permeabilization
- infiltration by
- complement activation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cfd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- complement activation, alternative pathway
- response to bacterium
- proteolysis
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular vesicular exosome
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- serine-type peptidase activity