Ltc4s Gene Summary [Rat]
Enables glutathione binding activity and leukotriene-C4 synthase activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to vitamin A; and leukotriene biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nuclear outer membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Biomarker of glomerulonephritis and peripheral nervous system disease. Orthologous to human LTC4S (leukotriene C4 synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ltc4s |
| Official Name | leukotriene C4 synthase [Source:RGD Symbol;Acc:620677] |
| Ensembl ID | ENSRNOG00000003244 |
| Bio databases IDs | |
| Aliases | leukotriene C4 synthase |
| Synonyms | Leukotriene C4 Synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ltc4s often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- binding protein
- MAPEG family
- enzyme
- protein binding
- leukotriene-C4 synthase
- identical protein binding
Pathways
Biological processes and signaling networks where the Ltc4s gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophilia
- hyperplasia
- airway hyperresponsiveness
- hypersensitivity reaction type I
- diabetic nephropathy
- urticaria
- anaphylaxis
- celiac disease
- hypersensitive reaction
- latent tuberculosis
role in cell
- activation
- accumulation
- formation in
- quantity
- mitogenesis
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular membrane-bounded organelle
- perinuclear membrane
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- outer nuclear membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ltc4s gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene biosynthetic process
- long-chain fatty acid biosynthetic process
- leukotriene metabolic process
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum membrane
- nuclear membrane
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- nuclear outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- glutathione peroxidase activity
- glutathione transferase activity
- enzyme activator activity
- lipid binding
- leukotriene-C4 synthase activity