Tgfb3 Gene Summary [Rat]
Predicted to enable several functions, including cytokine activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including regulation of signal transduction; response to estrogen; and skeletal system morphogenesis. Located in several cellular components, including T-tubule; neuronal cell body; and secretory granule. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tgfb3 |
| Official Name | transforming growth factor, beta 3 [Source:RGD Symbol;Acc:3851] |
| Ensembl ID | ENSRNOG00000009867 |
| Bio databases IDs | |
| Aliases | transforming growth factor, beta 3 |
| Synonyms | ARVD, ARVD1, LDS5, PTGF β, RNHF, TGF-beta-3, TGF-β-3, TRANSFORMING GROWTH FACTOR beta 3, transforming growth factor, beta 3, TRANSFORMING GROWTH FACTOR β 3, transforming growth factor, β 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tgfb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- punt binding
- binding protein
- transforming growth factor-beta receptor binding
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- TGFbeta binding
- identical protein binding
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Tgfb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Apelin Cardiac Fibroblast Signaling Pathway
- Aryl Hydrocarbon Receptor Signaling
- Cyclins and Cell Cycle Regulation
- Factors Promoting Cardiogenesis in Vertebrates
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-12 Signaling and Production in Macrophages
- IL-17 Signaling
- p38 MAPK Signaling
- Pancreatic Adenocarcinoma Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of Tissue Factor in Cancer
- TGF-β Signaling
- Tight Junction Signaling
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- breast carcinoma
- breast cancer
- breast or ovarian cancer
- urogenital cancer
- lymphoma
- lymphomagenesis
- Loeys-Dietz syndrome type 5
role in cell
- cell death
- apoptosis
- growth
- number
- activation in
- accumulation in
- proliferation
- expression in
- differentiation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- cell surface
- alpha granules
- transverse tubules
- secretory granules
- extracellular matrix
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tgfb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- frontal suture morphogenesis
- inner ear development
- response to estrogen stimulus
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- response to progesterone stimulus
- transforming growth factor beta receptor signaling pathway
- positive regulation of filopodium assembly
- odontogenesis
- positive regulation of transcription from RNA polymerase II promoter
- face morphogenesis
- salivary gland morphogenesis
- negative regulation of neuron apoptotic process
- positive regulation of epithelial to mesenchymal transition
- lung alveolus development
- response to hypoxia
- positive regulation of collagen biosynthetic process
- positive regulation of cell division
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- digestive tract development
- negative regulation of macrophage cytokine production
- detection of hypoxia
- positive regulation of protein secretion
- positive regulation of SMAD protein import into nucleus
- uterine wall breakdown
- embryonic neurocranium morphogenesis
- female pregnancy
- positive regulation of MAPK cascade
- cell-cell junction organization
- regulation of cell proliferation
- mammary gland development
- response to laminar fluid shear stress
- positive regulation of stress fiber assembly
- positive regulation of apoptotic process
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- T-tubule
- extracellular space
- intracellular membrane-bounded organelle
- neuronal cell body
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- identical protein binding
- growth factor activity
- protein binding
- type III transforming growth factor beta receptor binding
- type II transforming growth factor beta receptor binding
- cytokine activity
- type I transforming growth factor beta receptor binding