Col3a1 Gene Summary [Rat]
Predicted to enable several functions, including integrin binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent conferring tensile strength. Involved in response to mechanical stimulus and skeletal system development. Located in collagen-containing extracellular matrix. Biomarker of several diseases, including bladder neck obstruction; glomerulosclerosis; obesity; rheumatic heart disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome; Ehlers-Danlos syndrome hypermobility type; end stage renal disease; and vascular type Ehlers-Danlos syndrome. Orthologous to human COL3A1 (collagen type III alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col3a1 |
| Official Name | collagen type III alpha 1 chain [Source:RGD Symbol;Acc:71029] |
| Ensembl ID | ENSRNOG00000003357 |
| Bio databases IDs | |
| Aliases | collagen type III alpha 1 chain |
| Synonyms | Alpha coliii, CN3, Col3a, COL3 alpha, COL3 α, COL III, Collagen 3, collagen alpha 1 (III), Collagen III, collagen III alpha 1, collagen III α 1, Collagen Type 3, COLLAGEN type 3, alpha 1 CHAIN, COLLAGEN type 3, α 1 CHAIN, Collagen type III, collagen type III alpha 1, collagen, type III, alpha 1, collagen type III alpha 1 chain, Collagen type III pro α 1, collagen type III α 1, collagen, type III, α 1, collagen type III α 1 chain, collagen α 1 (III), EDS4A, EDSVASC, PMGEDSV, Procollagen3 Alpha1, procollagen alpha III, Procollagen III, Procollagen type III, PROCOLLAGEN type III alpha1, procollagen α III, Tsk2, type3 alpha1 PROCOLLAGEN, Type III collagen, α coliii |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col3a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- triple helical domain
- von Willebrand factor type C domain
- C-propeptide domain
- Fibrillar collagen C-terminal domain
- protease binding
- integrin binding
- extracellular matrix structural constituent
- Collagen triple helix repeat (20 copies)
- protein binding
- growth factor binding
Pathways
Biological processes and signaling networks where the Col3a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- diabetic foot ulcer disorder
- epithelial cancer
- rheumatoid arthritis
- Ehlers-Danlos syndrome type IV
- Dupuytren contracture
- ulcerative colitis
- Ehlers-Danlos syndrome
- familial aortic disorder
- familial thoracic aortic aneurysms and dissections
role in cell
- proliferation
- growth
- adhesion
- apoptosis
- expression in
- activation in
- production in
- migration
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- pial basement membrane
- endoplasmic reticulum lumen
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col3a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- multicellular organism growth
- layer formation in cerebral cortex
- positive regulation of Rho protein signal transduction
- response to radiation
- transforming growth factor beta receptor signaling pathway
- chondrocyte differentiation
- skin development
- fibroblast proliferation
- cellular response to amino acid stimulus
- heart development
- neuron migration
- integrin-mediated signaling pathway
- wound healing
- in utero embryonic development
- digestive tract development
- transforming growth factor beta1 production
- basement membrane organization
- negative regulation of immune response
- platelet activation
- negative regulation of neuron migration
- lung development
- cell-matrix adhesion
- endochondral bone morphogenesis
- limb joint morphogenesis
- cerebral cortex development
- aorta smooth muscle tissue morphogenesis
- tissue homeostasis
- elastic fiber assembly
- extracellular matrix organization
- collagen fibril organization
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
- collagen type III
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- metal ion binding
- extracellular matrix structural constituent conferring tensile strength
- protease binding
- integrin binding
- extracellular matrix structural constituent
- platelet-derived growth factor binding