Epn3 Gene Summary [Rat]
Predicted to enable EH domain binding activity; clathrin binding activity; and phospholipid binding activity. Predicted to be involved in endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; cytoplasmic side of plasma membrane; and perinuclear region of cytoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN3 (epsin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epn3 |
| Official Name | epsin 3 [Source:RGD Symbol;Acc:1306416] |
| Ensembl ID | ENSRNOG00000003284 |
| Bio databases IDs | |
| Aliases | epsin 3 |
| Synonyms | 2310022G12RIK, epsin 3, LOC102555637 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-interacting motif
- VHS, ENTH and ANTH domain superfamily
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the Epn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- vesicles
- cytoplasmic face of plasma membrane
- nucleoplasm
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- endosome
- perinuclear region of cytoplasm
- coated pit
- intracellular membrane-bounded organelle
- clathrin vesicle coat
- clathrin-coated vesicle
- plasma membrane
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin binding
- phospholipid binding