Epn3 Gene Summary [Mouse]
Enables EH domain binding activity. Predicted to be involved in endocytosis. Located in clathrin-coated pit. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and respiratory system. Orthologous to human EPN3 (epsin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epn3 |
| Official Name | epsin 3 [Source:MGI Symbol;Acc:MGI:1919139] |
| Ensembl ID | ENSMUSG00000010080 |
| Bio databases IDs | |
| Aliases | epsin 3 |
| Synonyms | 2310022G12RIK, epsin 3, LOC102555637 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-interacting motif
- VHS, ENTH and ANTH domain superfamily
- protein domain specific binding
- protein binding
Pathways
Biological processes and signaling networks where the Epn3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- vesicles
- cytoplasmic face of plasma membrane
- nucleoplasm
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endocytosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- endosome
- perinuclear region of cytoplasm
- coated pit
- intracellular membrane-bounded organelle
- clathrin vesicle coat
- clathrin-coated vesicle
- plasma membrane
- internal side of plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin binding
- phospholipid binding