Tlr9

Enables unmethylated CpG binding activity. Involved in several processes, including cellular response to lipopolysaccharide; microglial cell activation; and toll-like receptor signaling pathway. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Predicted to be active in early endosome membrane; endoplasmic reticulum; and plasma membrane. Biomarker of acute necrotizing pancreatitis; mastitis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tlr9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tlr9 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Tlr9 gene, providing context for its role in the cell.