Prdx4 Gene Summary [Rat]
Predicted to enable several functions, including identical protein binding activity; molecular sequestering activity; and thioredoxin peroxidase activity. Predicted to be involved in cell redox homeostasis; hydrogen peroxide catabolic process; and response to oxidative stress. Predicted to act upstream of or within several processes, including male gonad development; negative regulation of male germ cell proliferation; and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Located in extracellular space and smooth endoplasmic reticulum. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdx4 |
| Official Name | peroxiredoxin 4 [Source:RGD Symbol;Acc:620043] |
| Ensembl ID | ENSRNOG00000003763 |
| Bio databases IDs | |
| Aliases | peroxiredoxin 4 |
| Synonyms | AOE 37-2, HEL-S-97n, peroxiredoxin 4, PRX-4, Prx-IV, TRANK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prdx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxiredoxin
- C-terminal domain of 1-Cys peroxiredoxin
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- thioredoxin peroxidase
- AhpC/TSA family
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sensorimotor impairment
- lung adenocarcinoma
- lung adenocarcinoma formation
- oligozoospermia
- cognitive impairment
- neurodegeneration
- reactive gliosis
- laser induced choroidal neovascularization
role in cell
- apoptosis
- degradation in
- expression in
- proliferation
- cellular infiltration by
- phosphorylation in
- formation
- dysfunction
- organization
- dysfunction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Endoplasmic Reticulum
- cytosol
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prdx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- protein maturation by protein folding
- I-kappaB phosphorylation
- male gonad development
- spermatogenesis
- extracellular matrix organization
- cellular response to stress
- negative regulation of male germ cell proliferation
- cell redox homeostasis
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
- secretory granule lumen
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- thioredoxin peroxidase activity
- binding, bridging