PRDX4 Gene Summary [Human]
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRDX4 |
| Official Name | peroxiredoxin 4 [Source:HGNC Symbol;Acc:HGNC:17169] |
| Ensembl ID | ENSG00000123131 |
| Bio databases IDs | |
| Aliases | peroxiredoxin 4 |
| Synonyms | AOE 37-2, HEL-S-97n, peroxiredoxin 4, PRX-4, Prx-IV, TRANK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRDX4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxiredoxin
- C-terminal domain of 1-Cys peroxiredoxin
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- thioredoxin peroxidase
- AhpC/TSA family
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sensorimotor impairment
- lung adenocarcinoma
- lung adenocarcinoma formation
- oligozoospermia
- cognitive impairment
- neurodegeneration
- reactive gliosis
- laser induced choroidal neovascularization
role in cell
- apoptosis
- degradation in
- expression in
- proliferation
- cellular infiltration by
- phosphorylation in
- formation
- dysfunction
- organization
- dysfunction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Endoplasmic Reticulum
- cytosol
- smooth endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRDX4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- protein maturation by protein folding
- I-kappaB phosphorylation
- male gonad development
- spermatogenesis
- extracellular matrix organization
- cellular response to stress
- negative regulation of male germ cell proliferation
- cell redox homeostasis
- hydrogen peroxide catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
- secretory granule lumen
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- thioredoxin peroxidase activity
- binding, bridging