Ap2a2 Gene Summary [Rat]
Enables phosphatidylinositol binding activity and protein serine/threonine kinase binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Part of AP-2 adaptor complex. Is active in synaptic vesicle. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap2a2 |
| Official Name | adaptor related protein complex 2 subunit alpha 2 [Source:RGD Symbol;Acc:71015] |
| Ensembl ID | ENSRNOG00000019534 |
| Bio databases IDs | |
| Aliases | adaptor related protein complex 2 subunit alpha 2 |
| Synonyms | 2410074K14Rik, Adaptin alpha, Adaptin α, adaptor-related protein complex 2, alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2, adaptor related protein complex 2 subunit α 2, adaptor-related protein complex 2, α 2 subunit, ADTAB, Alpha-adaptin C, Ap2 alpha, Ap2 alpha C, AP-2 alpha C subunit, Ap2 α, Ap2 α C, AP-2 α C subunit, CLAPA2, HIP-9, HYPJ, L25, LOC101927462, α-adaptin C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ap2a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Adaptin C-terminal domain
- protein binding activity, bridging
- protein domain specific binding
- protein binding
- phosphatidylinositol binding
- appendage domain
- kinase binding
- binding protein
- ear domain
- Adaptin N terminal region
- Alpha adaptin AP2, C-terminal domain
- trunk domain
- transporter
Pathways
Biological processes and signaling networks where the Ap2a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- Alzheimer disease
- nicotine withdrawal syndrome
- rotator cuff injury
- peptic ulcer disease
role in cell
- apoptosis
- cell viability
- transmembrane potential
- formation
- trafficking
- G1 phase
- endocytosis
- endocytosis by
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- nuclear fraction
- polyribosome fractions
- endocytic vesicle membrane
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- secretory granule membrane
- cytosol
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- nerve ending
- synapse
- cytoplasmic vesicles
- secretory granules
- clathrin-coated pits
- clathrin-coated vesicles
- plasma
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ap2a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- vesicle-mediated transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- clathrin-coated endocytic vesicle membrane
- endolysosome membrane
- cytosol
- cytoplasmic vesicle
- AP-2 adaptor complex
- clathrin-coated endocytic vesicle
- endocytic vesicle membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- lipid binding
- clathrin adaptor activity