Rgs18 Gene Summary [Rat]
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Orthologous to human RGS18 (regulator of G protein signaling 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs18 |
| Official Name | regulator of G-protein signaling 18 [Source:RGD Symbol;Acc:1306522] |
| Ensembl ID | ENSRNOG00000003959 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 18 |
| Synonyms | LOC103690097, regulator of G-protein signaling 18, RGS13 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgs18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Rgs18 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- androgenic alopecia
role in cell
- expression in
- migration
- aggregation
- differentiation
- survival
- activation in
- quantity
- production
- accumulation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgs18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activity
- GTPase activator activity