Itga2b Gene Summary [Rat]
Enables fibrinogen binding activity. Involved in positive regulation of leukocyte migration. Located in cell surface. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itga2b |
| Official Name | integrin subunit alpha 2b [Source:RGD Symbol;Acc:1596428] |
| Ensembl ID | ENSRNOG00000022071 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 2b |
| Synonyms | alpha 2B, alphaIIb, BDPLT16, BDPLT2, CD41, Cd41a, CD41B, GP2B, GPIIb, GT, GT1, GTA, HPA3, integrin alpha 2b, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), integrin alpha-IIb, integrin subunit alpha 2b, integrin subunit α 2b, Integrin α 2b, integrin α-IIb, LOC688210, PPP1R93, α 2B, αIIb |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itga2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fibrinogen binding domain
- calf-2 domain
- Integrin alpha cytoplasmic region
- extracellular domain
- extracellular matrix binding
- helical domain
- calcium binding loop
- protein binding
- identical protein binding
- FG-GAP-like repeat
- Integrin alpha (beta-propellor repeats)
- binding protein
- Integrin alpha
- cytoplasmic domain
- transmembrane domain
- cytosolic tail domain
- FG-GAP repeat
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Itga2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- GP6 Signaling Pathway
- HGF Signaling
- Integrin Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Serotonin Receptor Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial ischemia
- stroke
- thromboembolism
- unstable angina
- non-ST elevation myocardial infarction
- Glanzmann thrombasthenia, type 1
- acute myeloid leukemia
- acute ischemic stroke
- Glanzmann thrombasthenia
- stenosis
role in cell
- proliferation
- migration
- activation in
- adhesion
- activation
- aggregation
- binding
- phosphorylation in
- binding in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell periphery
- microvesicles
- cellular membrane
- focal adhesions
- Golgi Apparatus
- Endoplasmic Reticulum
- plasma membrane extracellular face
- alpha granules
- membrane rafts
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itga2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- positive regulation of leukocyte migration
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- angiogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- platelet alpha granule membrane
- focal adhesion
- alphaIIb-beta3 integrin complex
- blood microparticle
- external side of plasma membrane
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- identical protein binding
- fibrinogen binding
- protein binding
- metal ion binding
- integrin binding
- binding, bridging