Eno3 Gene Summary [Rat]
Enables identical protein binding activity and phosphopyruvate hydratase activity. Involved in response to xenobiotic stimulus and skeletal muscle tissue regeneration. Predicted to be located in plasma membrane. Predicted to be part of phosphopyruvate hydratase complex. Predicted to be active in cytosol. Biomarker of aortic valve stenosis. Orthologous to human ENO3 (enolase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eno3 |
| Official Name | enolase 3 [Source:RGD Symbol;Acc:2555] |
| Ensembl ID | ENSRNOG00000004078 |
| Bio databases IDs | |
| Aliases | enolase 3 |
| Synonyms | BBE, Beta enolase, ENOLASE 3, enolase 3, beta muscle, enolase 3, β muscle, GSD13, MSE, β enolase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eno3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enolase_like
- Enolase, C-terminal TIM barrel domain
- binding protein
- TIM-like beta/alpha barrel domains
- phosphopyruvate hydratase
- enzyme
- protein binding
- Enolase, N-terminal domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- aldosterone producing adrenocortical adenoma
- adenoma formation
- hepatocellular carcinoma
- liver cancer
- amyotrophic lateral sclerosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- glycogen storage disease XIII
role in cell
- glycolysis in
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eno3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- glycolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- cytosol
- phosphopyruvate hydratase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- phosphopyruvate hydratase activity