Ikbke Gene Summary [Rat]
Predicted to enable several functions, including IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to virus; positive regulation of gene expression; and positive regulation of innate immune response. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ikbke |
| Official Name | inhibitor of nuclear factor kappa B kinase subunit epsilon [Source:RGD Symbol;Acc:1308352] |
| Ensembl ID | ENSRNOG00000025100 |
| Bio databases IDs | |
| Aliases | inhibitor of nuclear factor kappa B kinase subunit epsilon |
| Synonyms | Ikb ε, IKK-E, IKK epsilon, IKK-i, IKK ε, Inhibitor of kappa b kinase epsilon, inhibitor of kappaB kinase ε, inhibitor of nuclear factor kappa B kinase subunit epsilon, inhibitor of nuclear factor κ B kinase subunit ε, Inhibitor of κ b kinase ε, i κ b kinase ε, KIAA0151 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ikbke often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TANK-binding kinase 1 coiled-coil domain 1
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- coiled-coil domain
- protein binding
- ubiquitin-like domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- TBK1_IKKE-like_C
- kinase domain
- Protein Kinases, catalytic domain
- Ubl1_cv_Nsp3_N-like
- ikappaB kinase
- TANK binding kinase 1 ubiquitin-like domain
- ABC1 atypical kinase-like domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Ikbke gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Angiopoietin Signaling
- Antioxidant Action of Vitamin C
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- IL-17A Signaling in Airway Cells
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- Lymphotoxin β Receptor Signaling
- Myc Mediated Apoptosis Signaling
- NF-κB Activation by Viruses
- PEDF Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- metastasis
- weight loss
- cardiac hypertrophy
- fibrosis
- COVID-19
- alcoholic steatohepatitis
- IgA nephropathy
- psoriasis
role in cell
- expression in
- transcription in
- apoptosis
- proliferation
- activation in
- cell death
- binding in
- phosphorylation in
- production in
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- granules
- cytosol
- mitochondrial membrane
- nucleoplasm
- PML nuclear bodies
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ikbke gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon production
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of protein complex assembly
- DNA damage response, signal transduction resulting in induction of apoptosis
- positive regulation of sequence-specific DNA binding transcription factor activity
- type I interferon-mediated signaling pathway
- immune response
- mRNA stabilization
- defense response to virus
- gene expression
- peptidyl-serine phosphorylation
- response to interferon-beta
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial membrane
- PML body
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein phosphatase binding
- protein binding
- ubiquitin protein ligase binding
- K63-linked polyubiquitin binding
- IkappaB kinase activity
- protein serine/threonine kinase activity