Rpl26 Gene Summary [Rat]
Predicted to enable mRNA 5'-UTR binding activity. Predicted to be a structural constituent of ribosome. Involved in response to amino acid starvation. Located in terminal bouton. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 11. Orthologous to several human genes including RPL26 (ribosomal protein L26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl26 |
| Official Name | ribosomal protein L26 [Source:RGD Symbol;Acc:1310607] |
| Ensembl ID | ENSRNOG00000004214 |
| Bio databases IDs | |
| Aliases | ribosomal protein L26 |
| Synonyms | DBA11, Elongation factor 1-beta, Elongation factor 1-β, L26, ribosomal protein L26, SIG-20, uL24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rpl26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- mRNA 5' UTR binding
- Ribosomal proteins L26 eukaryotic, L24P archaeal
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl26 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synapse
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rpl26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gamma radiation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- positive regulation of translation
- cytoplasmic translation
- ribosomal large subunit biogenesis
- cellular response to UV
- rRNA processing
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- synapse
- cytosolic large ribosomal subunit
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- mRNA 5'-UTR binding