Rpl26 Gene Summary [Mouse]
A structural constituent of ribosome. Involved in DNA damage response, signal transduction by p53 class mediator; cellular response to ionizing radiation; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in 1-cell stage embryo; 2-cell stage embryo; and 4-cell stage embryo. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 11. Orthologous to several human genes including RPL26 (ribosomal protein L26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl26 |
| Official Name | ribosomal protein L26 [Source:MGI Symbol;Acc:MGI:106022] |
| Ensembl ID | ENSMUSG00000060938 |
| Bio databases IDs | |
| Aliases | ribosomal protein L26 |
| Synonyms | DBA11, Elongation factor 1-beta, Elongation factor 1-β, L26, ribosomal protein L26, SIG-20, uL24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- 6-pyruvoyl-tetrahydropterin synthase related domain (membrane protein)
- mRNA 5' UTR binding
- Ribosomal proteins L26 eukaryotic, L24P archaeal
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl26 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synapse
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gamma radiation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- positive regulation of translation
- cytoplasmic translation
- ribosomal large subunit biogenesis
- cellular response to UV
- rRNA processing
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- synapse
- cytosolic large ribosomal subunit
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- mRNA 5'-UTR binding