Sptssa Gene Summary [Rat]
Predicted to contribute to serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process; protein localization; and sphingosine biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 90A and hereditary spastic paraplegia 90B. Orthologous to human SPTSSA (serine palmitoyltransferase small subunit A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sptssa |
| Official Name | serine palmitoyltransferase, small subunit A [Source:RGD Symbol;Acc:1565821] |
| Ensembl ID | ENSRNOG00000004292 |
| Bio databases IDs | |
| Aliases | serine palmitoyltransferase, small subunit A |
| Synonyms | 1110002B05Rik, C14orf147, MGC112883, serine palmitoyltransferase small subunit A, serine palmitoyltransferase, small subunit A, SPG90A, SPG90B, SSSPTA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sptssa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small subunit of serine palmitoyltransferase-like
- serine C-palmitoyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Sptssa gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- autosomal recessive spastic paraplegia type 90B
- autosomal dominant spastic paraplegia type 90A
- psoriasis
role in cell
- expression in
- phagocytosis by
- autophagy by
- phagocytosis
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sptssa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sphingosine biosynthetic process
- protein localization
- ceramide biosynthetic process
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- serine C-palmitoyltransferase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine C-palmitoyltransferase activity