Upp1 Gene Summary [Rat]
Predicted to enable identical protein binding activity and pyrimidine-nucleoside phosphorylase activity. Involved in cellular response to glucose starvation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of middle cerebral artery infarction. Orthologous to human UPP1 (uridine phosphorylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upp1 |
| Official Name | uridine phosphorylase 1 [Source:RGD Symbol;Acc:1305566] |
| Ensembl ID | ENSRNOG00000004972 |
| Bio databases IDs | |
| Aliases | uridine phosphorylase 1 |
| Synonyms | UDRPASE, UP, UPASE, UPP, UrdPase 1, Uridine phosphorylase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Upp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine phosphorylase
- nucleoside phosphorylase-I family
- thymidine phosphorylase
- enzyme
- identical protein binding
- deoxyuridine phosphorylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- neoplasia
- squamous cell cancer
- edema
- squamous-cell carcinoma
- carcinoma in situ
- epithelial cancer in situ
- kyphosis
- tumor
- organismal death
role in cell
- expression in
- proliferation
- growth
- apoptosis
- formation
- extracellular acidification rate property
- abnormal morphology
- oxygen consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- filamentous network
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Upp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dTMP catabolic process
- uridine catabolic process
- dUMP catabolic process
- CMP catabolic process
- UMP catabolic process
- dCMP catabolic process
- nucleobase-containing compound metabolic process
- cellular response to glucose starvation
- UMP salvage
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- thymidine phosphorylase activity
- uridine phosphorylase activity
- deoxyuridine phosphorylase activity