Adss Gene Summary [Rat]
Enables adenylosuccinate synthase activity. Involved in several processes, including IMP metabolic process; aspartate metabolic process; and cellular response to electrical stimulus. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Biomarker of sarcoma. Orthologous to human ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adss |
| Official Name | adenylosuccinate synthase [Source:RGD Symbol;Acc:1310508] |
| Ensembl ID | ENSRNOG00000004481 |
| Bio databases IDs | |
| Aliases | adenylosuccinate synthase |
| Synonyms | ADEH, adenylosuccinate synthase 2, ADSS, AS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adss often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adenylosuccinate synthetase
- adenylosuccinate synthase
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Adss gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adss gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' AMP biosynthetic process
- IMP metabolic process
- response to purine-containing compound
- AMP biosynthetic process
- aspartate metabolic process
- cellular response to electrical stimulus
- immune system process
- response to ammonium ion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- adenylosuccinate synthase activity
- protein binding
- phosphate ion binding