Begain Gene Summary [Rat]
Predicted to be involved in evoked excitatory postsynaptic potential and regulation of postsynaptic neurotransmitter receptor activity. Located in several cellular components, including dendrite; neuronal cell body; and synapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human BEGAIN (brain enriched guanylate kinase associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Begain |
| Official Name | brain-enriched guanylate kinase-associated [Source:RGD Symbol;Acc:708347] |
| Ensembl ID | ENSRNOG00000004650 |
| Bio databases IDs | |
| Aliases | brain-enriched guanylate kinase-associated |
| Synonyms | BEGIN, brain-enriched guanylate kinase-associated, Gm897 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Begain often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4515)
- Ciliary protein causing Leber congenital amaurosis disease
- Ezrin/radixin/moesin, alpha-helical domain
- Tup N-terminal
- leucine zipper domain
- protein binding
- FlgN protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- synaptic plasma membrane fractions
- nuclear fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- postsynaptic region
- cellular membrane
- cytosol
- neurites
- synaptosomes
- synapse
- perikaryon
- dendrites
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Begain gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding