Fzd10 Gene Summary [Rat]
Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway; non-canonical Wnt signaling pathway; and positive regulation of JNK cascade. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cell surface; cytoplasm; and nucleoplasm. Predicted to be active in extracellular space. Orthologous to human FZD10 (frizzled class receptor 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Pseudogene |
| Official Symbol | Fzd10 |
| Official Name | frizzled class receptor 10 [Source:RGD Symbol;Acc:1583825] |
| Ensembl ID | ENSRNOG00000022784 |
| Bio databases IDs | |
| Aliases | frizzled class receptor 10 |
| Synonyms | CD350, frizzled class receptor 10, FZ-10, Fzd10-ps1, FzE7, hFz10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fzd10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Wnt-protein binding
- Frizzled/Smoothened family membrane region
- Wnt receptor
- Fz domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- cysteine rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the Fzd10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cervical cancer
- alveolar soft part sarcoma
- soft tissue sarcoma cancer
- colorectal cancer
- salivary gland mucoepidermoid carcinoma
- salivary gland cancer
- androgenic alopecia
- gastric cancer
- clear cell sarcoma of the kidney
regulates
- ERK
- MKI67
role in cell
- expression in
- phosphorylation in
- growth
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fzd10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin cytoskeleton organization
- G-protein coupled receptor signaling pathway
- neuron differentiation
- cellular response to retinoic acid
- positive regulation of JNK cascade
- canonical Wnt receptor signaling pathway
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- Wnt-activated receptor activity
- protein binding
- Wnt-protein binding