Pop1 Gene Summary [Rat]
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal and tRNA decay. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Orthologous to human POP1 (POP1 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pop1 |
| Official Name | POP1 homolog, ribonuclease P/MRP subunit [Source:RGD Symbol;Acc:1308609] |
| Ensembl ID | ENSRNOG00000005243 |
| Bio databases IDs | |
| Aliases | POP1 homolog, ribonuclease P/MRP subunit |
| Synonyms | 4932434G09Rik, ANXD2, POP1 homolog, ribonuclease P/MRP subunit, processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pop1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease P
- Ribonucleases P/MRP protein subunit POP1
- enzyme
- protein binding
- POPLD (NUC188) domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleolar region
- metaphase plate
- nucleoplasm
- nucleolus derived foci
- nucleoli
- mitotic spindle
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pop1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- tRNA catabolic process
- tRNA 5'-leader removal
Cellular Component
Where in the cell the gene product is active
- extracellular space
- ribonuclease MRP complex
- multimeric ribonuclease P complex
- nucleolus
- nucleolar ribonuclease P complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease P activity
- protein binding
- RNA binding
- ribonuclease P RNA binding