Ccnt1 Gene Summary [Rat]
Predicted to enable several functions, including 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and enzyme binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of P-TEFb complex. Predicted to be active in nucleus. Orthologous to human CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnt1 |
| Official Name | cyclin T1 [Source:RGD Symbol;Acc:1311151] |
| Ensembl ID | ENSRNOG00000053054 |
| Bio databases IDs | |
| Aliases | cyclin T1 |
| Synonyms | 2810478G24RIK, CCNT, Cyclin T, cyclin T1, CYCT1, HIVE1, LOC103692976, LOC144438 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin N-terminal domain
- transcription regulator
- cyclin box
- Cyclin box fold superfamily
- protein binding activity, bridging
- transcription factor binding
- chromatin binding
- coiled-coil domain
- domain present in cyclins, TFIIB and Retinoblastoma
- serine-rich region
- TAR binding domain
- Cyclin, N-terminal domain
- Tat-TAR recognition motif
- snRNA binding
- protein kinase binding
- nucleic acid binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- cyclin-dependent protein kinase regulator
- DNA binding
- cyclin-CDK binding domain
- protein kinase activator
- PEST domain
- double-stranded DNA binding
- Tat binding domain
- histidine-rich region
- TAT recognition domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- expression in
- apoptosis
- differentiation
- transmembrane potential
- production in
- replication in
- morphology
- cellular infiltration by
- Clathrin mediated endocytosis by
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- positive regulation by host of viral transcription
- cell division
- transcription from RNA polymerase II promoter
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation, DNA-dependent
- regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- dimeric positive transcription elongation factor complex b
- cytosol
- positive transcription elongation factor complex b
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- DNA binding
- protein kinase binding
- protein binding
- transcription regulatory region sequence-specific DNA binding
- chromatin binding