Dhrs7 Gene Summary [Rat]
Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity and carbonyl reductase (NADPH) activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human DHRS7 (dehydrogenase/reductase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhrs7 |
| Official Name | dehydrogenase/reductase 7 [Source:RGD Symbol;Acc:1565002] |
| Ensembl ID | ENSRNOG00000005589 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase 7 |
| Synonyms | 2310016E22Rik, 5730564L20RIK, CGI-86, dehydrogenase/reductase 7, DKFZp564H1664, retDSR4, retSDR4, RGD1565002, SDR34C1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dhrs7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- sepiapterin reductase
- CH-OH group:NAD or NADP oxidoreductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- carbonyl reductase (NADPH)
Pathways
Biological processes and signaling networks where the Dhrs7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dhrs7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- carbonyl reductase (NADPH) activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- NADP-retinol dehydrogenase activity