Grm7

Enables several functions, including PDZ domain binding activity; calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; postsynaptic membrane; and presynaptic active zone. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Grm7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Grm7 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Grm7 gene, providing context for its role in the cell.