Pomc Gene Summary [Rat]
Predicted to enable hormone activity and melanocortin receptor binding activity. Involved in several processes, including motor behavior; negative regulation of inflammatory response to antigenic stimulus; and response to lipopolysaccharide. Located in extracellular region and neuronal cell body. Used to study alcohol dependence; heroin dependence; and obesity. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; obesity; opiate dependence (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pomc |
| Official Name | proopiomelanocortin [Source:RGD Symbol;Acc:3366] |
| Ensembl ID | ENSRNOG00000012686 |
| Bio databases IDs | |
| Aliases | proopiomelanocortin |
| Synonyms | BE, beta-LIPOTROPIN, Beta-LPH, beta-MSH, CLIP, Endorphin beta, Endorphin β, Gamma-LPH, gamma MSH, Ir beta Ep, Ir β Ep, LPH, MSH, Msh α, NPP, OBAIRH, POC, Pomc-1, POMC2, proopiomelanocortin, pro-opiomelanocortin-alpha, pro-opiomelanocortin-α, β-LIPOTROPIN, β-LPH, β-MSH, γ-LPH, γ MSH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pomc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- Corticotropin ACTH domain
- hormone
- protein binding
- receptor binding
- cleavage site
- Opioids neuropeptide
- Pro-opiomelanocortin, N-terminal region
- sorting signal domain
Pathways
Biological processes and signaling networks where the Pomc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- bleeding
- insulin resistance
- obesity
- weight gain
- Cushing syndrome
- hyperleptinemia
- hypoglycemia
role in cell
- accumulation
- phosphorylation in
- expression in
- accumulation in
- activity
- signaling in
- activation in
- proliferation
- invasion by
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- peroxisomal matrix
- secretory granule lumen
- Cytoplasm
- perinuclear Golgi regions
- cell periphery
- perinuclear region
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- granules
- cytosol
- microsome
- trans Golgi network
- Golgi cisternae rim
- cytoplasmic vesicles
- melanosomes
- peroxisomes
- secretory granules
- Golgi cisternae
- membrane processes
- perikaryon
- axons
- dendrites
- immature secretory granules
- dense core granules
- mature secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pomc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- regulation of appetite
- signal transduction
- cell-cell signaling
- positive regulation of transcription from RNA polymerase II promoter
- regulation of blood pressure
- neuropeptide signaling pathway
- glucose homeostasis
- cellular pigmentation
- regulation of corticosterone secretion
- regulation of glycogen metabolic process
- calcium-mediated signaling
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- secretory granule
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- type 1 melanocortin receptor binding
- type 3 melanocortin receptor binding
- type 4 melanocortin receptor binding
- receptor binding
- hormone activity