Bmp7 Gene Summary [Rat]
Enables heparin binding activity. Involved in several processes, including response to estradiol; response to peptide hormone; and response to vitamin D. Located in collagen-containing extracellular matrix; extracellular space; and vesicle. Biomarker of acute kidney tubular necrosis; kidney disease; nephroblastoma; and pyelonephritis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp7 |
| Official Name | bone morphogenetic protein 7 [Source:RGD Symbol;Acc:620743] |
| Ensembl ID | ENSRNOG00000053384 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 7 |
| Synonyms | bone morphogenetic protein 7, OP-1, osteogenic protein 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- receptor binding
- cytokine
- pro domain
- heparin binding
- growth factor
- TGF-beta propeptide
Pathways
Biological processes and signaling networks where the Bmp7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Cardiomyocyte Differentiation via BMP Receptors
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- TGF-β Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microalbuminuria
- metabolic syndrome X
- bleeding
- ovarian cancer
- weight loss
- diabetes mellitus
- colorectal cancer
- metastasis
- breast carcinoma
- polysyndactyly
role in cell
- migration
- expression in
- formation in
- proliferation
- apoptosis
- activation in
- quantity
- synthesis in
- molecular cleavage in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- vesicles
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchyme development
- positive regulation of brown fat cell differentiation
- axon guidance
- branching morphogenesis of a tube
- negative regulation of prostatic bud formation
- branching involved in salivary gland morphogenesis
- regulation of branching involved in prostate gland morphogenesis
- skeletal system development
- negative regulation of transcription, DNA-dependent
- hindbrain development
- ossification
- positive regulation of transcription, DNA-dependent
- cellular response to BMP stimulus
- mesenchymal cell differentiation
- BMP signaling pathway
- mesonephros development
- monocyte aggregation
- mesoderm formation
- cellular response to hypoxia
- positive regulation of bone mineralization
- embryonic skeletal joint morphogenesis
- negative regulation of NF-kappaB transcription factor activity
- embryonic pattern specification
- neural fold elevation formation
- pharyngeal system development
- positive regulation of hyaluranon cable assembly
- response to peptide hormone stimulus
- pericardium morphogenesis
- chorio-allantoic fusion
- metanephric mesenchymal cell proliferation involved in metanephros development
- positive regulation of epithelial cell differentiation
- positive regulation of gene expression
- nephrogenic mesenchyme morphogenesis
- metanephric mesenchyme morphogenesis
- response to estradiol stimulus
- epithelial to mesenchymal transition
- negative regulation of neurogenesis
- regulation of removal of superoxide radicals
- negative regulation of striated muscle cell apoptotic process
- cartilage development
- response to vitamin D
- negative regulation of neuron differentiation
- endocardial cushion formation
- neuron projection morphogenesis
- negative regulation of cell cycle
- positive regulation of neuron differentiation
- odontogenesis of dentin-containing tooth
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- negative regulation of Notch signaling pathway
- cardiac muscle tissue development
- positive regulation of epithelial to mesenchymal transition
- embryonic limb morphogenesis
- negative regulation of glomerular mesangial cell proliferation
- positive regulation of SMAD protein import into nucleus
- dendrite development
- negative regulation of mitosis
- heart trabecula morphogenesis
- negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis
- cardiac septum morphogenesis
- positive regulation of dendrite development
- regulation of phosphorylation
- metanephros development
- ureteric bud development
- positive regulation of apoptotic process
- embryonic camera-type eye morphogenesis
- positive regulation of heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- heparin binding
- cytokine activity
- BMP receptor binding