Rin3 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in signal transduction and vesicle-mediated transport. Predicted to act upstream of or within negative regulation of receptor internalization and regulation of vesicle size. Predicted to be located in several cellular components, including dendrite; early endosome; and neuronal cell body. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rin3 |
| Official Name | Ras and Rab interactor 3 [Source:RGD Symbol;Acc:1305849] |
| Ensembl ID | ENSRNOG00000007062 |
| Bio databases IDs | |
| Aliases | Ras and Rab interactor 3 |
| Synonyms | 6430500K07, C86933, FLJ22439, Ras and Rab interactor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- VPS9p domain
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- Vacuolar sorting protein 9 (VPS9) domain
- enzyme binding
- Src homology 2 (SH2) domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- asthma
- lung cancer
- chronic obstructive pulmonary disease
- Alzheimer disease
- colorectal cancer
- endometriosis
- rheumatoid arthritis
- organismal death
- gastroesophageal reflux
role in cell
- cell viability
- migration
- binding in
- formation in
- formation
- chemotaxis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- vesicles
- cytosol
- early endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of receptor internalization
- signal transduction
- endocytosis
- negative regulation of mast cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- dendrite
- early endosome
- cytoplasm
- cytoplasmic vesicle
- cytosol
- vesicle
- neuronal cell body
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding