Nell2 Gene Summary [Rat]
Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Located in several cellular components, including dendrite; extracellular space; and perikaryon. Orthologous to human NELL2 (neural EGFL like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nell2 |
| Official Name | neural EGFL like 2 [Source:RGD Symbol;Acc:620999] |
| Ensembl ID | ENSRNOG00000006235 |
| Bio databases IDs | |
| Aliases | neural EGFL like 2 |
| Synonyms | A330108N19Rik, LOC100365444, LOC681834, mel91, NEL-like 2, neural EGFL like 2, NRP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nell2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- von Willebrand factor type C domain
- LamG
- protein kinase C binding
- calcium ion binding
- EGF domain
- protein binding
- heparin binding
- identical protein binding
- laminin G domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- systemic autoimmune syndrome
- Wilms tumor
- Wilms tumorigenesis
- septic shock
- sepsis
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- schizophrenia
regulates
- ERK1/2
- hormone
- N-cadherin
- ROBO3
role in cell
- survival
- phosphorylation in
- long-term potentiation
- fertilization
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nell2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- fertilization
- commissural neuron axon guidance
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- identical protein binding
- protein binding
- calcium ion binding
- heparin binding