Fyco1 Gene Summary [Rat]
Predicted to enable zinc ion binding activity. Predicted to be involved in plus-end-directed vesicle transport along microtubule and positive regulation of autophagosome maturation. Predicted to be located in Golgi apparatus. Predicted to be active in autophagosome; late endosome; and lysosome. Human ortholog(s) of this gene implicated in cataract 18. Orthologous to human FYCO1 (FYVE and coiled-coil domain autophagy adaptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fyco1 |
| Official Name | FYVE and coiled-coil domain containing 1 [Source:RGD Symbol;Acc:1309069] |
| Ensembl ID | ENSRNOG00000006336 |
| Bio databases IDs | |
| Aliases | FYVE and coiled-coil domain containing 1 |
| Synonyms | 2810409M01Rik, CATC2, CTRCT18, FYVE and coiled-coil domain autophagy adaptor 1, FYVE and coiled-coil domain containing 1, Mem2, RUFY3, ZFYVE7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fyco1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- FYVE zinc finger
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Hyaluronan mediated motility receptor N-terminal
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Protein of unknown function (DUF745)
- GPCR-chaperone
- FYVE domain like superfamily
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- Golgi-dynamics membrane-trafficking
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- autosomal recessive congenital cataract type 2
- hereditary disorder
- cataract disease
- severe COVID-19
- Hutchinson-Gilford progeria syndrome
- suicide attempt
- congenital cataract
- covid-19 death
- glycogen storage disease type II
regulates
- Gelatin
- phospholipid
- Kinesin-1
- CTSD
role in cell
- maturation
- degradation in
- degradation by
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- vesicles
- lysosome
- Golgi Apparatus
- autophagic vacuoles
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fyco1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plus-end-directed vesicle transport along microtubule
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- late endosome
- Golgi apparatus
- autophagic vacuole
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding