Mbd3l1 Gene Summary [Rat]
Predicted to enable methyl-CpG binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human MBD3L1 (methyl-CpG binding domain protein 3 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mbd3l1 |
| Official Name | methyl-CpG binding domain protein 3-like 1 [Source:RGD Symbol;Acc:1308259] |
| Ensembl ID | ENSRNOG00000006363 |
| Bio databases IDs | |
| Aliases | methyl-CpG binding domain protein 3-like 1 |
| Synonyms | 1700070G05Rik, 1700095H13Rik, MBD3L, methyl-CpG binding domain protein 3-like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mbd3l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p55-binding region of Methyl-CpG-binding domain proteins MBD
- protein binding
- C-terminal domain of methyl-CpG binding protein 2 and 3
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mbd3l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- methylation-dependent chromatin silencing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- methyl-CpG binding