Tbc1d10a Gene Summary [Rat]
Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Orthologous to human TBC1D10A (TBC1 domain family member 10A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d10a |
| Official Name | TBC1 domain family, member 10a [Source:RGD Symbol;Acc:1311641] |
| Ensembl ID | ENSRNOG00000006394 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 10a |
| Synonyms | AI447804, dJ130H16.1, dJ130H16.2, EPI64, mFLJ00288, TBC1D10, TBC1 domain family member 10A, TBC1 domain family, member 10a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbc1d10a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Domain in Tre-2, BUB2p, and Cdc16p
- GTPase activator
- protein binding
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
role in cell
- expression in
- formation
- accumulation in
- accumulation
- autophagy in
- exocytosis
- exocytosis by
- trafficking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- apical membrane
- basolateral membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbc1d10a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of cysteine-type endopeptidase activity
- positive regulation of proteolysis
- retrograde transport, endosome to Golgi
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- microvillus
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- PDZ domain binding