Rab28 Gene Summary [Rat]
Enables GTP binding activity. Predicted to be involved in intracellular protein transport. Located in ciliary basal body and ciliary rootlet. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab28 |
| Official Name | RAB28, member RAS oncogene family [Source:RGD Symbol;Acc:620891] |
| Ensembl ID | ENSRNOG00000017074 |
| Bio databases IDs | |
| Aliases | RAB28, member RAS oncogene family |
| Synonyms | 2700023P08Rik, AW496496, CORD18, RAB28, member RAS oncogene family |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rab28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- cone-rod dystrophy
- cone-rod dystrophy type 18
- RAB28-related retinopathy
- cone dystrophy
- rotator cuff injury
- infection by HIV-1
- productive infection by HIV-1
regulates
role in cell
- number
- apoptosis
- migration
- activation in
- proliferation
- enlargement
- degeneration
- replication in
- abnormal morphology
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basal bodies
- ciliary rootlet
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rab28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- cytoplasm
- cilium basal body
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding