Pgk1 Gene Summary [Rat]
Enables ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Involved in gluconeogenesis and glycolytic process. Predicted to be located in extracellular space; membrane raft; and mitochondrial matrix. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to human PGK1 (phosphoglycerate kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgk1 |
| Official Name | phosphoglycerate kinase 1 [Source:RGD Symbol;Acc:619878] |
| Ensembl ID | ENSRNOG00000058249 |
| Bio databases IDs | |
| Aliases | phosphoglycerate kinase 1 |
| Synonyms | HEL-S-68p, MIG10, Pgk, PGKA, Phosphoglycerate kinase 1, X-Chromosome Linked Phosphoglycerate Kinase, X-LINKED PHOSPHOGLYCERATE KINASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pgk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Phosphoglycerate_kinase
- ADP binding
- phosphoglycerate kinase
- ATP binding
- protein binding
- protein-disulfide reductase
Pathways
Biological processes and signaling networks where the Pgk1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- head and neck neoplasia
- phosphoglycerate kinase 1 deficiency
- variant phosphoglycerate kinase deficiency
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- colorectal cancer
- organismal death
- rheumatoid arthritis
role in cell
- growth
- phosphorylation in
- binding in
- expression in
- production in
- proliferation
- number
- association
- glycolysis in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- extracellular vesicles
- Extracellular Space
- cellular membrane
- Nucleus
- lysosome
- cytosol
- mitochondrial matrix
- membrane rafts
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pgk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- negative regulation of angiogenesis
- gluconeogenesis
- plasminogen activation
- glycolysis
- cellular response to hypoxia
- phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- membrane raft
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phosphoglycerate kinase activity
- protein-disulfide reductase activity
- ADP binding