Borcs5 Gene Summary [Rat]
Predicted to be involved in lysosome localization; organelle transport along microtubule; and positive regulation of anterograde synaptic vesicle transport. Predicted to act upstream of or within nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be part of BORC complex and plus-end kinesin complex. Predicted to be active in axon; cytoplasmic side of lysosomal membrane; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Borcs5 |
| Official Name | BLOC-1 related complex subunit 5 [Source:RGD Symbol;Acc:1307624] |
| Ensembl ID | ENSRNOG00000006505 |
| Bio databases IDs | |
| Aliases | BLOC-1 related complex subunit 5 |
| Synonyms | 5830457J20RIK, BLOC-1 related complex subunit 5, LOH12, LOH12CR1, LOH1CR12, Myrlysin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Borcs5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- BLOC-1-related complex subunit 5, and related proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- acute respiratory distress syndrome
- colorectal cancer
- acne
- male pattern hair loss
regulated by
role in cell
- quantity
- accumulation in
- accumulation
- dynamics
- dynamics in
- autophagy in
- transport
- autophagy
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- lysosome
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Borcs5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- organelle transport along microtubule
- regulation of endosome size
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- synaptic vesicle membrane
- plus-end kinesin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding