H3f3a Gene Summary [Rat]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Involved in response to hormone. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 2. Orthologous to several human genes including H3-3B (H3.3 histone B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | H3f3a |
| Official Name | H3 histone family member 3A [Source:RGD Symbol;Acc:2319910] |
| Ensembl ID | ENSRNOG00000006532 |
| Bio databases IDs | |
| Aliases | H3 histone family member 3A |
| Synonyms | 9430068D06RIK, BRYLIB2, H3-3A, H3.3B, H3.3 histone B, H3F3B, HISTONE 3B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat H3f3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of chromatin
- histone fold domain (HFD) superfamily
- binding protein
- double-stranded DNA binding
- nucleic acid binding
- Core histone H2A/H2B/H3/H4
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Histone H3
Pathways
Biological processes and signaling networks where the H3f3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- chronic kidney disease
- Bryant-Li-Bhoj neurodevelopmental syndrome 2
- androgenic alopecia
- Parkinson disease
- breast cancer
- growth failure
- hereditary disorder
- neurodevelopmental disorder
role in cell
- expression in
- differentiation
- formation
- binding in
- proliferation
- cell death
- quantity
- growth
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- nucleosomes
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat H3f3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- multicellular organism growth
- male gonad development
- spermatid development
- regulation of centromere complex assembly
- single fertilization
- nucleus organization
- embryo implantation
- nucleosome assembly
- positive regulation of cell growth
- oocyte maturation
- telomeric heterochromatin assembly
- centromeric heterochromatin assembly
- muscle cell differentiation
- osteoblast differentiation
- telomere organization
Cellular Component
Where in the cell the gene product is active
- Barr body
- chromosome, telomeric region
- nucleus
- condensed chromosome inner kinetochore
- extracellular vesicular exosome
- macromolecular complex
- extracellular region
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- structural constituent of chromatin
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter sequence-specific DNA binding
- nucleosomal DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding