Mcm5 Gene Summary [Rat]
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA replication initiation and double-strand break repair via break-induced replication. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and MCM complex. Predicted to be active in nucleus. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 8. Orthologous to human MCM5 (minichromosome maintenance complex component 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm5 |
| Official Name | minichromosome maintenance complex component 5 [Source:RGD Symbol;Acc:1306616] |
| Ensembl ID | ENSRNOG00000014336 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 5 |
| Synonyms | CDC46, Mcmd5, MGORS8, minichromosome maintenance complex component 5, P1-CDC46 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mcm5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase domain
- minichromosome maintenance proteins
- MCM OB domain
- ATP-binding domain
- ATPase domain
- MCM N-terminal domain
- MCM P-loop domain
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- MCM AAA-lid domain
- MCM helicase family
Pathways
Biological processes and signaling networks where the Mcm5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- Meier-Gorlin syndrome type 8
- cervical cancer
- psoriatic arthritis
- colon cancer
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- plexiform neurofibroma
role in cell
- growth
- migration
- survival
- invasion by
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- cytosol
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mcm5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- double-strand break repair via break-induced replication
- DNA replication
- regulation of DNA-dependent DNA replication initiation
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- CMG complex
- membrane
- MCM complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA replication origin binding
- protein binding
- 3'-5' DNA helicase activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- single-stranded DNA binding