H3f3b Gene Summary [Mouse]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | H3f3b |
| Official Name | H3.3 histone B [Source:MGI Symbol;Acc:MGI:1101768] |
| Ensembl ID | ENSMUSG00000016559 |
| Bio databases IDs | |
| Aliases | H3.3 histone B |
| Synonyms | 9430068D06RIK, BRYLIB2, H3-3A, H3.3B, H3.3 histone B, H3F3B, HISTONE 3B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H3f3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of chromatin
- histone fold domain (HFD) superfamily
- binding protein
- double-stranded DNA binding
- nucleic acid binding
- Core histone H2A/H2B/H3/H4
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Histone H3
Pathways
Biological processes and signaling networks where the H3f3b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- chronic kidney disease
- Bryant-Li-Bhoj neurodevelopmental syndrome 2
- androgenic alopecia
- Parkinson disease
- breast cancer
- growth failure
- hereditary disorder
- neurodevelopmental disorder
role in cell
- expression in
- differentiation
- formation
- binding in
- proliferation
- cell death
- quantity
- growth
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- nucleosomes
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H3f3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- multicellular organism growth
- male gonad development
- spermatid development
- regulation of centromere complex assembly
- single fertilization
- nucleus organization
- embryo implantation
- nucleosome assembly
- positive regulation of cell growth
- oocyte maturation
- telomeric heterochromatin assembly
- centromeric heterochromatin assembly
- muscle cell differentiation
- osteoblast differentiation
- telomere organization
Cellular Component
Where in the cell the gene product is active
- Barr body
- chromosome, telomeric region
- nucleus
- condensed chromosome inner kinetochore
- extracellular vesicular exosome
- macromolecular complex
- extracellular region
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- structural constituent of chromatin
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter sequence-specific DNA binding
- nucleosomal DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding