Dbh Gene Summary [Rat]
Enables copper ion binding activity and dopamine beta-monooxygenase activity. Involved in several processes, including cellular response to manganese ion; cellular response to nicotine; and norepinephrine biosynthetic process. Located in several cellular components, including axon; dendrite; and neuronal cell body. Biomarker of brain ischemia; depressive disorder; hypertension; and portal hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dbh |
| Official Name | dopamine beta-hydroxylase [Source:RGD Symbol;Acc:2489] |
| Ensembl ID | ENSRNOG00000006641 |
| Bio databases IDs | |
| Aliases | dopamine beta-hydroxylase |
| Synonyms | DBM, DOPAMINE beta-HYDROXYLASE, dopamine beta-monooxygenase, DOPAMINE β-HYDROXYLASE, dopamine β-monooxygenase, DOPBHY, ORTHYP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dbh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Copper type II ascorbate-dependent monooxygenase, C-terminal domain
- copper ion binding
- Domon-like ligand-binding domains
- DOMON domain
- Copper type II ascorbate-dependent monooxygenase, N-terminal domain
- enzyme
- protein binding
- dopamine beta-monooxygenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- squamous cell lung cancer
- insulin resistance
- recurrent glioblastoma
- hereditary disorder
- alcoholism
- growth failure
- dopamine beta-hydroxylase deficiency
- seizures
- bladder cancer
role in cell
- expression in
- migration
- development
- immune protection by
- conversion in
- production
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axon component
- intracellular membrane-bounded organelle
- secretory granule lumen
- Extracellular Space
- cell periphery
- apical compartment
- cellular membrane
- vesicles
- centrosome
- Endoplasmic Reticulum
- secretory granule membrane
- secretory granules
- membrane processes
- perikaryon
- axons
- dendrites
- axon terminals
- chromaffin vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dbh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homoiothermy
- positive regulation of vasoconstriction
- synaptic transmission
- visual learning
- fear response
- dopamine catabolic process
- vasoconstriction
- behavioral response to ethanol
- norepinephrine biosynthetic process
- octopamine biosynthetic process
- memory
- leukocyte mediated immunity
- maternal behavior
- response to pain
- blood vessel remodeling
- locomotory behavior
- response to amphetamine
- glucose homeostasis
- regulation of extrinsic apoptotic signaling pathway
- leukocyte migration
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- chromaffin granule membrane
- endoplasmic reticulum
- synapse
- extracellular region
- secretory granule membrane
- extracellular space
- transport vesicle membrane
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- chromaffin granule lumen
- secretory granule lumen
Molecular Function
What the gene product does at the molecular level
- L-ascorbic acid binding
- protein binding
- copper ion binding
- catalytic activity
- dopamine beta-monooxygenase activity