Spc25 Gene Summary [Rat]
Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic spindle organization. Predicted to be located in cytosol and kinetochore. Predicted to be part of Ndc80 complex. Orthologous to human SPC25 (SPC25 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spc25 |
| Official Name | SPC25 component of NDC80 kinetochore complex [Source:RGD Symbol;Acc:1307811] |
| Ensembl ID | ENSRNOG00000006731 |
| Bio databases IDs | |
| Aliases | SPC25 component of NDC80 kinetochore complex |
| Synonyms | 2600017H08RIK, 2610205L13Rik, AD024, hSpc25, RGD1307811, SPBC25, SPC25 component of NDC80 kinetochore complex, SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spc25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RWD, DRWD, and ELF domain family
- Chromosome segregation protein Spc25
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- kidney disease
- metabolic syndrome X
- uterine serous papillary cancer
- dysglycemia
- lymphomagenesis
- B cell cancer
- lung adenocarcinoma
role in cell
- cell death
- apoptosis
- survival
- cell viability
- quantity
- colony formation
- attachment
- organization
- elongation
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spc25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- mitotic spindle organization
- attachment of spindle microtubules to kinetochore
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Ndc80 complex
- cytosol
- kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding