Laptm4b Gene Summary [Rat]
Predicted to enable ceramide binding activity; enzyme binding activity; and phosphatidylinositol bisphosphate binding activity. Predicted to be involved in several processes, including endosome transport via multivesicular body sorting pathway; negative regulation of macromolecule metabolic process; and regulation of lysosomal membrane permeability. Predicted to be located in several cellular components, including endosome; lysosome; and plasma membrane. Predicted to be active in lysosomal membrane. Orthologous to human LAPTM4B (lysosomal protein transmembrane 4 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Laptm4b |
| Official Name | lysosomal protein transmembrane 4 beta [Source:RGD Symbol;Acc:1311853] |
| Ensembl ID | ENSRNOG00000006766 |
| Bio databases IDs | |
| Aliases | lysosomal protein transmembrane 4 beta |
| Synonyms | APTM4B, C330023P13Rik, LAPTM4beta, LC27, Lysosomal-associated protein transmembrane 4b, lysosomal protein transmembrane 4 beta, lysosomal protein transmembrane 4 β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Laptm4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Golgi 4-transmembrane spanning transporter
- ubiquitin protein ligase binding
- sphingolipid binding
- kinase binding
- binding protein
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- immunodeficiency
- gastric cancer
- Huntington disease
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- osteosarcoma
- osteosarcomagenesis
role in cell
- phosphorylation in
- binding in
- activation in
- accumulation in
- apoptosis
- survival
- colony formation
- organization
- release
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endosomes
- lysosome
- lysosome membrane
- endosomal membrane
- early endosomes
- cytoplasmic vesicles
- multivesicular bodies
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Laptm4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transforming growth factor beta1 production
- endosome organization
- regulation of lysosomal membrane permeability
- endosome transport via multivesicular body sorting pathway
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- early endosome
- endosome
- multivesicular body membrane
- cell projection
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- protein binding
- ubiquitin protein ligase binding
- kinase binding