Fbp1 Gene Summary [Rat]
Enables fructose 1,6-bisphosphate 1-phosphatase activity and monosaccharide binding activity. Involved in several processes, including cellular response to cAMP; cellular response to phorbol 13-acetate 12-myristate; and cellular response to salt stress. Located in extracellular space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbp1 |
| Official Name | fructose-bisphosphatase 1 [Source:RGD Symbol;Acc:2595] |
| Ensembl ID | ENSRNOG00000017597 |
| Bio databases IDs | |
| Aliases | fructose-bisphosphatase 1 |
| Synonyms | F1:6 biphosphatase, FBP, Fbp-2, FBP3, FBPase, Fdp, Fructose biphosphatase, fructose-bisphosphatase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AMP binding
- monosaccharide binding
- phosphatase
- fructose-bisphosphatase
- metal ion binding
- transcription factor binding
- enzyme
- protein binding
- FIG
- identical protein binding
- Fructose-1-6-bisphosphatase, C-terminal domain
Pathways
Biological processes and signaling networks where the Fbp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- fructose-1,6-diphosphatase deficiency
- neoplasia
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
- liver cancer
- organismal death
- hepatocellular carcinoma
- epithelial cancer
role in cell
- apoptosis
- expression in
- transactivation in
- phosphorylation in
- accumulation in
- proliferation
- growth
- response by
- production in
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- fructose 6-phosphate metabolic process
- negative regulation of glycolysis
- fructose metabolic process
- regulation of gluconeogenesis
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- sucrose biosynthetic process
- negative regulation of Ras protein signal transduction
- cellular hyperosmotic salinity response
- negative regulation of cell growth
- cellular response to magnesium ion
- cellular response to cAMP
- cellular response to xenobiotic stimulus
- cellular hypotonic salinity response
- dephosphorylation
- response to nutrient levels
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- AMP binding
- protein binding
- metal ion binding
- fructose 1,6-bisphosphate 1-phosphatase activity
- monosaccharide binding