Bdkrb1 Gene Summary [Rat]
Enables bradykinin receptor activity and peptide binding activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; and response to lipopolysaccharide. Predicted to be active in plasma membrane. Used to study several diseases, including diabetic angiopathy; hypertension; neuropathy (multiple); overactive bladder syndrome; and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bdkrb1 |
| Official Name | bradykinin receptor B1 [Source:RGD Symbol;Acc:620401] |
| Ensembl ID | ENSRNOG00000004488 |
| Bio databases IDs | |
| Aliases | bradykinin receptor B1 |
| Synonyms | B1BKR, B1R, Bdkrb, BKB1R, BKR, BKR1, BRADYB1, Bradykinin b1 receptor, bradykinin receptor B1, bradykinin receptor, beta 1, bradykinin receptor, β 1, KININ B1 receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bdkrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- peptide binding
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- bradykinin receptor
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Bdkrb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- cognitive impairment
- hypoalgesia
- glomerulosclerosis
- endotoxin shock response
- neuroinflammation
- renal fibrosis
- renal impairment
- keratocystic odontogenic tumor
role in cell
- activation in
- apoptosis
- growth
- adhesion
- production in
- signaling in
- migration
- emigration
- invasiveness
- interaction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bdkrb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- negative regulation of blood pressure
- positive regulation of release of sequestered calcium ion into cytosol
- protein kinase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
- response to mechanical stimulus
- positive regulation of leukocyte migration
- inflammatory response
- negative regulation of cell growth
- negative regulation of protein phosphorylation
- response to lipopolysaccharide
- cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- bradykinin receptor activity
- peptide binding