Rffl Gene Summary [Rat]
Predicted to enable ATP-dependent DNA damage sensor activity; gamma-tubulin binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Predicted to be involved in DNA strand invasion; double-strand break repair via homologous recombination; and telomere maintenance via recombination. Predicted to act upstream of or within chromosome organization; interstrand cross-link repair; and regulation of cell cycle. Predicted to be located in centrosome; chromosome, telomeric region; and replication fork. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Human ortholog(s) of this gene implicated in hereditary breast ovarian cancer syndrome. Orthologous to human RAD51D (RAD51 paralog D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rffl |
| Official Name | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [Source:RGD Symbol;Acc:727916] |
| Ensembl ID | ENSRNOG00000007596 |
| Bio databases IDs | |
| Aliases | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
| Synonyms | 1700051E09Rik, 4930516L10Rik, CARP-2, Endothelial and Smooth Muscle Cell-derived Neuropilin-like Molecule, FRING, RIFIFYLIN, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase, ring finger and FYVE like domain containing protein, RNF189, RNF34L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rffl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- ubiquitin protein ligase binding
- protein kinase binding
- protease binding
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- enzyme
- p53 binding
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
role in cell
- activation in
- expression in
- replication in
- migration
- degradation in
- differentiation
- G1 phase
- migration by
- polyubiquitination in
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomal membrane
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rffl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- negative regulation of tumor necrosis factor-mediated signaling pathway
- apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
- ubiquitin-dependent protein catabolic process
- regulation of fibroblast migration
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- endosome membrane
- Golgi membrane
- recycling endosome membrane
- plasma membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- p53 binding
- ubiquitin protein ligase binding
- protein binding
- metal ion binding
- protease binding