Stx5 Gene Summary [Rat]
Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in Golgi membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx5 |
| Official Name | syntaxin 5 [Source:RGD Symbol;Acc:68426] |
| Ensembl ID | ENSRNOG00000018847 |
| Bio databases IDs | |
| Aliases | syntaxin 5 |
| Synonyms | 0610031F24Rik, CDG2AA, D19Ertd627e, SED5, STX5A, syntaxin 5, syntaxin 5A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- cytoplasmic domain
- Helical region found in SNAREs
- transmembrane domain
- coiled-coil domain
- protein binding
- Syntaxin-5 N-terminal, Sly1p-binding domain
- SNARE motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type IIaa
- infection by HIV-1
regulates
- progesterone
- CFTR
role in cell
- production in
- assembly
- replication in
- spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- pH resistant lipid raft fraction
- perinuclear Golgi regions
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- transport vesicles
- microsomal membrane
- phagosomes
- medial Golgi cisternae
- cis Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- vesicle fusion
- Golgi disassembly
- vesicle docking
- positive regulation of protein catabolic process
- early endosome to Golgi transport
- intracellular protein transport
- retrograde transport, endosome to Golgi
- vesicle fusion with Golgi apparatus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER to Golgi transport vesicle membrane
- vesicle
- SNARE complex
- endomembrane system
- cytosol
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- SNAP receptor activity
- SNARE binding