N4bp2l2 Gene Summary [Rat]
Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of hematopoietic stem cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of hematopoietic stem cell proliferation. Predicted to act upstream of or within blastocyst development. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human N4BP2L2 (NEDD4 binding protein 2 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | N4bp2l2 |
| Official Name | NEDD4 binding protein 2-like 2 [Source:RGD Symbol;Acc:1359603] |
| Ensembl ID | ENSRNOG00000001108 |
| Bio databases IDs | |
| Aliases | NEDD4 binding protein 2-like 2 |
| Synonyms | 92M18.3, CG005, CG016, LOC100909860, LOC88523, NEDD4 binding protein 2-like 2, PFAAP5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat N4bp2l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- enzyme binding
- protein binding
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- colorectal cancer
- myocardial infarction
- coronary artery disease
- hemimegalencephaly
regulates
- synthetic promoter
- ELANE
- CAT reporter gene
- AZU1
role in cell
- expression in
- differentiation
- proliferation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat N4bp2l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- blastocyst development
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- transcriptional repressor complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- enzyme binding