Dnaja1 Gene Summary [Rat]
Enables ATPase activator activity. Predicted to be involved in several processes, including negative regulation of protein modification process; regulation of apoptotic process; and regulation of establishment of protein localization. Predicted to act upstream of or within androgen receptor signaling pathway; flagellated sperm motility; and spermatogenesis. Predicted to be located in membrane and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnaja1 |
| Official Name | DnaJ heat shock protein family (Hsp40) member A1 [Source:RGD Symbol;Acc:620942] |
| Ensembl ID | ENSRNOG00000007029 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member A1 |
| Synonyms | DJ-2, DjA1, DnaJ heat shock protein family (Hsp40) member A1, DNAJL2, HDJ, HDJ2, Heat shock 40-kDa protein 4, HSDJ, HSJ-2, HSPF4, NEDD7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnaja1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- ubiquitin protein ligase binding
- chaperone protein DnaJ
- DnaJ central domain
- Hsp70 protein binding
- G-protein-coupled receptor binding
- transcription factor binding
- protein domain specific binding
- low-density lipoprotein receptor binding
- protein binding
- DnaJ domain
- Zinc finger domain of DnaJ and HSP40
- DnaJ
- DnaJ molecular chaperone homology domain
- DnaJ C terminal domain
- Ubl1_cv_Nsp3_N-like
- chaperone binding
Pathways
Biological processes and signaling networks where the Dnaja1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- colorectal cancer
- neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- peripheral arterial disease
- Huntington disease
- androgenic alopecia
- asthenozoospermia
- growth failure
role in cell
- apoptosis
- degradation in
- proliferation
- expression in
- fragmentation in
- cell death
- migration
- survival
- motility
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- microtubule cytoskeleton
- cellular membrane
- cytosol
- synaptic vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnaja1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of JUN kinase activity
- spermatogenesis
- protein folding
- protein refolding
- response to unfolded protein
- response to heat
- sperm motility
- regulation of protein transport
- protein localization in mitochondrion
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- negative regulation of protein ubiquitination
- androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- C3HC4-type RING finger domain binding
- unfolded protein binding
- ATPase activator activity
- ATP binding
- G-protein coupled receptor binding
- protein binding
- low-density lipoprotein particle receptor binding
- ubiquitin protein ligase binding
- metal ion binding
- Tat protein binding
- chaperone binding
- Hsp70 protein binding