Ankrd6 Gene Summary [Rat]
Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to act upstream of or within positive regulation of Wnt signaling pathway, planar cell polarity pathway. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in nucleus. Orthologous to human ANKRD6 (ankyrin repeat domain 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ankrd6 |
| Official Name | ankyrin repeat domain 6 [Source:RGD Symbol;Acc:1583731] |
| Ensembl ID | ENSRNOG00000007110 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 6 |
| Synonyms | ankyrin repeat domain 6, DIVERSIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ankrd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- metabolic syndrome X
- osteoarthritis
- bipolar disorder
- peripheral arterial disease
- epileptic seizure
- infection by HIV-1
regulates
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ankrd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of JNK cascade
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle