Dvl1 Gene Summary [Rat]
Enables protein kinase binding activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron projection arborization. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dvl1 |
| Official Name | dishevelled segment polarity protein 1 [Source:RGD Symbol;Acc:620632] |
| Ensembl ID | ENSRNOG00000019423 |
| Bio databases IDs | |
| Aliases | dishevelled segment polarity protein 1 |
| Synonyms | DISHEVELED, dishevelled segment polarity protein 1, DRS2, DSH, DVL, DVL1L1, DVL1P1, mKIAA4029 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dvl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DIX domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- frizzled binding
- beta-catenin binding
- canonical PDZ domain
- enzyme binding
- protein binding
- PDZ domain
- identical protein binding
- Segment polarity protein dishevelled (Dsh) C terminal
- DEP
- Dishevelled specific domain
- cpPDZ_Deg_HtrA-like
Pathways
Biological processes and signaling networks where the Dvl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- autosomal dominant Robinow syndrome type 2
- exencephaly
- left ventricular dysfunction
- cardiac hypertrophy
- depressive disorder
- autosomal dominant Robinow syndrome type 1
- uterine leiomyoma
- leiomyomatosis
- perivascular fibrosis
role in cell
- apoptosis
- phosphorylation in
- signaling in
- activation in
- accumulation in
- growth
- formation
- production in
- molecular cleavage in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- microtubule cytoskeleton
- presynaptic regions
- cell surface
- perinuclear region
- focal adhesions
- Nucleus
- Plasma Membrane
- microtubules
- actin filaments
- cell-cell contacts
- cytoplasmic particles
- cytosol
- apical membrane
- basal membrane
- lateral plasma membrane
- dendritic spines
- growth cone
- neurites
- synapse
- cytoplasmic vesicles
- actin stress fibers
- secretory granules
- membrane processes
- cell membrane leading edge
- perikaryon
- axons
- dendrites
- postsynaptic density
- clathrin-coated vesicles
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dvl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- planar cell polarity pathway involved in neural tube closure
- outflow tract morphogenesis
- axon guidance
- convergent extension involved in neural plate elongation
- positive regulation of transcription from RNA polymerase II promoter
- dendrite morphogenesis
- neuromuscular junction development
- heart looping
- canonical Wnt receptor signaling pathway
- positive regulation of neuron projection development
- Wnt receptor signaling pathway, planar cell polarity pathway
- synaptic vesicle exocytosis
- protein localization to nucleus
- intracellular signal transduction
- social behavior
- prepulse inhibition
- regulation of protein localization
- synapse organization
- cochlea morphogenesis
- protein localization to microtubule
- collateral sprouting
- regulation of transcription, DNA-dependent
- receptor clustering
- neurotransmitter secretion
- dendritic spine morphogenesis
- skeletal muscle acetylcholine-gated channel clustering
- axon extension
- negative regulation of protein phosphorylation
- positive regulation of protein phosphorylation
- regulation of synaptic vesicle exocytosis
- positive regulation of excitatory postsynaptic membrane potential
- cytoplasmic microtubule organization
- protein stabilization
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- growth cone
- postsynaptic density
- lateral plasma membrane
- dendritic spine
- cytosol
- cytoplasmic vesicle
- neuronal cell body
- synapse
- clathrin-coated vesicle
- neuron projection
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- frizzled binding
- identical protein binding
- protein binding
- small GTPase binding
- beta-catenin binding
- enzyme binding