Ankrd6 Gene Summary [Mouse]
This gene encodes a protein which is thought to be involved in the Wnt signaling pathway and embryonic axis formation. Similar genes have been found in human, rhesus macaque, and zebrafish. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Ankrd6 |
| Official Name | ankyrin repeat domain 6 [Source:MGI Symbol;Acc:MGI:2154278] |
| Ensembl ID | ENSMUSG00000040183 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 6 |
| Synonyms | ankyrin repeat domain 6, DIVERSIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ankrd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- COVID-19
- metabolic syndrome X
- osteoarthritis
- bipolar disorder
- peripheral arterial disease
- epileptic seizure
- infection by HIV-1
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ankrd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of JNK cascade
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle